Research Archive

The ingredients in RunStrong have been subject to extensive research and testing. Below is a list of reputable studies detailing the effects of each of these ingredients in various types of sport and in regard to other health benefits.


L-Carnitine L-Tartrate / Carnipure®

  1. L-Carnitine Tartrate Supplementation for 5 weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial.
  2. Influence of L-carnitine administration on maximal physical exercise.
  3. Supplementation of L-carnitine in athletes: does it make sense?
  4. The effects of acute L-carnitine supplementation on endurance performance of athletes.
  5. l-Carnitine Supplementation in Recovery after Exercise.
  6. L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress.
  7. Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate.
  8. Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males.
  9. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.
  10. Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase activities in muscle of endurance athletes.
  11. Respiratory chain enzymes in muscle of endurance athletes: effect of L-carnitine.
  12. The effects of acute L-carnitine supplementation on endurance performance of athletes.
  13. A Dose-Dependent Effect of Carnipure Tartrate Supplementation on Endurance Capacity, Recovery, and Body Composition in an Exercise Rat Model.
  14. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis.
  15. An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle.
  16. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle.
  17. Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans.
  18. The Effects Of L-carnitine And Exercise On Health Risk Factors In Obese High-school Girls. doi: 10.1249/01.MSS.0000385004.59061.93
  19. The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery.<0455:teolls>;2
  20. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort.
  21. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women.
  22. Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration.

Curcumin / Curcumin C3 Complex® 
  1. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).
  2. Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review.
  3. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation.
  4. The effect of curcumin supplementation on recovery following exercise-induced muscle damage and delayed-onset muscle soreness: A systematic review and meta-analysis of randomized controlled trials.
  5. Effects of curcumin supplementation on sport and physical exercise: a systematic review.
  6. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage.
  7. Curcumin: A Review of Its Effects on Human Health.
  8. Effects of curcumin supplementation on sport and physical exercise: a systematic review.
  9. Antioxidant and anti-inflammatory properties of curcumin.
  10. Curcumin, inflammation, ageing and age-related diseases. Immunity & ageing
  11. Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.
  12. The Effects of Eight Weeks Interval Training and Curcumin Consumption on TNF-α and BDNF Levels in Men with Metabolic Syndrome.
  13. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.
  14. Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.
  15. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
  16. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging.
  17. Dietary Supplements for Health, Adaptation, and Recovery in Athletes.
  18. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.
  19. Reflections about Osteoarthritis and Curcuma longa.
  20. Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis.
  21. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
  22. Curcumin and obesity.
  23. Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation. BMC complementary and alternative medicine.
  24. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).
  25. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review.
  26. Curcumin Improves Delayed Onset Muscle Soreness And Postexercise Lactate Accumulation.
  27. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin.
  28. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study.
  29. Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats.
  30. Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway.

  1. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
  2. Curcumin: A Review of Its Effects on Human Health. Foods
  3. Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications.
  4. Piperine and Its Role in Chronic Diseases.
  5. Piper nigrum and piperine: an update. Phytotherapy research.
  6. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.

Iron Bisglycinate
  1. Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis.
  2. Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications.
  3. Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials.
  4. Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.
  5. Iron considerations for the athlete: a narrative review.
  6. Effects of iron repletion on blood volume and performance capacity in young athletes.
  7. Recent Advances in Iron Metabolism: Relevance for Health, Exercise, and Performance.
  8. Foot-strike haemolysis in an ultramarathon runner.
  9. Runner's anemia.
  10. Footstrike is the major cause of hemolysis during running.
  11. Sport-related hematuria: a review.
  12. Iron deficiency in sports - definition, influence on performance and therapy.
  13. Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis.
  14. Treatment of iron deficiency anemia induces weight loss and improves metabolic parameters.

Vitamin D3 (Cholecalciferol, from algae)
  1. Dietary Supplements for Health, Adaptation, and Recovery in Athletes. 
  2. The Effect of Abnormal Vitamin D Levels in Athletes.
  3. Sports Health Benefits of Vitamin D.
  4. The effects of indoor and outdoor sports participation and seasonal changes on vitamin D levels in athletes.
  5. Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends.
  6. Vitamin D and the Immune System.
  7. Vitamin D and bone health: potential mechanisms.
  8. Evaluating the relationship of calcium and vitamin D in the prevention of stress fracture injuries in the young athlete: a review of the literature.
  9. Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly.
  10. Vitamin D and the immune system.
  11. Vitamin D and adipogenesis: new molecular insights.
  12. Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes.
  13. Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines.