The ingredients in RunStrong have been subject to extensive research and testing. Below is a list of reputable studies detailing the effects of each of these ingredients in various types of sport and in regard to other health benefits.
L-Carnitine L-Tartrate / Carnipure®
- L-Carnitine Tartrate Supplementation for 5 weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. https://doi.org/10.3390/nu13103432
- Influence of L-carnitine administration on maximal physical exercise. https://doi.org/10.1007/BF00236072
- Supplementation of L-carnitine in athletes: does it make sense? https://doi.org/10.1016/j.nut.2004.04.003
- The effects of acute L-carnitine supplementation on endurance performance of athletes. https://doi.org/10.1519/JSC.0b013e3182a76790
- l-Carnitine Supplementation in Recovery after Exercise. https://doi.org/10.3390/nu10030349
- L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. https://doi.org/10.1152/ajpendo.00277.2001
- Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. https://doi.org/10.1519/00124278-200702000-00046
- Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. https://doi.org/10.20463/jenb.2018.0026
- Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. https://doi.org/10.1113/jphysiol.2010.201343
- Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase activities in muscle of endurance athletes. https://doi.org/10.1016/0014-5793(94)80246-7
- Respiratory chain enzymes in muscle of endurance athletes: effect of L-carnitine. https://doi.org/10.1016/0006-291x(92)92355-2
- The effects of acute L-carnitine supplementation on endurance performance of athletes. https://doi.org/10.1519/JSC.0b013e3182a76790
- A Dose-Dependent Effect of Carnipure Tartrate Supplementation on Endurance Capacity, Recovery, and Body Composition in an Exercise Rat Model. https://doi.org/10.3390/nu12051519
- Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. https://doi.org/10.1016/j.clnesp.2020.03.008
- An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. https://doi.org/10.1210/jc.2006-1584
- New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. https://doi.org/10.1113/jphysiol.2006.125799
- Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans. https://doi.org/10.1113/jphysiol.2013.255364
- The Effects Of L-carnitine And Exercise On Health Risk Factors In Obese High-school Girls. doi: 10.1249/01.MSS.0000385004.59061.93
- The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. https://doi.org/10.1519/1533-4287(2003)017<0455:teolls>2.0.co;2
- Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. https://doi.org/10.1055/s-2007-972854
- l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. https://doi.org/10.1016/j.metabol.2009.11.012
- Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration. https://doi.org/10.1002/mus.880140703
Curcumin / Curcumin C3 Complex®
- Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). https://doi.org/10.1007/s00421-015-3152-6
- Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review. https://doi.org/10.3390/nu12020501
- Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. https://doi.org/10.1111/sms.13373
- The effect of curcumin supplementation on recovery following exercise-induced muscle damage and delayed-onset muscle soreness: A systematic review and meta-analysis of randomized controlled trials. https://doi.org/10.1002/ptr.6912
- Effects of curcumin supplementation on sport and physical exercise: a systematic review. https://doi.org/10.1080/10408398.2020.1749025
- Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. https://doi.org/10.1152/ajpregu.00858.2006
- Curcumin: A Review of Its Effects on Human Health. https://doi.org/10.3390/foods6100092
- Effects of curcumin supplementation on sport and physical exercise: a systematic review. https://doi.org/10.1080/10408398.2020.1749025
- Antioxidant and anti-inflammatory properties of curcumin. https://doi.org/10.1007/978-0-387-46401-5_3
- Curcumin, inflammation, ageing and age-related diseases. Immunity & ageing https://doi.org/10.1186/1742-4933-7-1
- Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. https://doi.org/10.1186/s13063-019-3327-2
- The Effects of Eight Weeks Interval Training and Curcumin Consumption on TNF-α and BDNF Levels in Men with Metabolic Syndrome. http://jarums.arums.ac.ir/article-1-1451-en.html
- Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. https://doi.org/10.1038/sj.onc.1208169
- Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. https://doi.org/10.3389/fphar.2020.01021
- Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. https://doi.org/10.1016/j.nutres.2012.09.002
- Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. https://doi.org/10.18632/oncotarget.24729
- Dietary Supplements for Health, Adaptation, and Recovery in Athletes. http://journals.humankinetics.com/view/journals/ijsnem/28/2/article-p188.xml
- A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. https://doi.org/10.1002/ptr.4639
- Reflections about Osteoarthritis and Curcuma longa. https://doi.org/10.4103/phrev.phrev_54_16
- Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis. https://doi.org/10.2147/DDDT.S78277
- Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. https://doi.org/10.1089/jmf.2016.3705
- Curcumin and obesity. https://doi.org/10.1002/biof.1074
- Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation. BMC complementary and alternative medicine. https://doi.org/10.1186/s12906-016-1307-6
- Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). https://doi.org/10.1007/s00421-015-3152-6
- Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. https://bmjopensem.bmj.com/content/7/1/e000935
- Curcumin Improves Delayed Onset Muscle Soreness And Postexercise Lactate Accumulation. https://doi.org/10.1080/19390211.2020.1796885
- Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. https://doi.org/10.1016/j.bbacli.2016.02.003
- Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. https://pubmed.ncbi.nlm.nih.gov/26592847
- Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats. https://pubmed.ncbi.nlm.nih.gov/28839007
- Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway. https://pubmed.ncbi.nlm.nih.gov/27208389
BioPerine®
- Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. https://doi.org/10.1055/s-2006-957450
- Curcumin: A Review of Its Effects on Human Health. Foods https://doi.org/10.3390/foods6100092
- Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications. https://doi.org/10.3390/nu12061886
- Piperine and Its Role in Chronic Diseases. https://doi.org/10.1007/978-3-319-41334-1_8
- Piper nigrum and piperine: an update. Phytotherapy research. https://doi.org/10.1002/ptr.4972
- Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. https://doi.org/10.1186/ar2662
Iron Bisglycinate
- Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis. https://doi.org/10.1136/bjsports-2014-093624
- Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications. https://doi.org/10.3390/nu12061886
- Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials. https://doi.org/10.1136/bmjopen-2017-019240
- Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial. https://doi.org/10.2174/1573396314666181002170040
- Iron considerations for the athlete: a narrative review. https://doi.org/10.1007/s00421-019-04157-y
- Effects of iron repletion on blood volume and performance capacity in young athletes. https://doi.org/10.1097/00005768-200105000-00010
- Recent Advances in Iron Metabolism: Relevance for Health, Exercise, and Performance. https://doi.org/10.1249/MSS.0000000000000593
- Foot-strike haemolysis in an ultramarathon runner. https://doi.org/10.1136/bcr-2017-220661
- Runner's anemia. https://doi.org/10.1001/jama.286.6.714
- Footstrike is the major cause of hemolysis during running. https://doi.org/10.1152/japplphysiol.00631.2001
- Sport-related hematuria: a review. https://doi.org/10.1097/00042752-199704000-00008
- Iron deficiency in sports - definition, influence on performance and therapy. https://doi.org/10.4414/smw.2015.14196
- Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis. https://doi.org/10.3945/jn.113.189589
- Treatment of iron deficiency anemia induces weight loss and improves metabolic parameters. https://pubmed.ncbi.nlm.nih.gov/24770833
Vitamin D3 (Cholecalciferol, from algae)
- Dietary Supplements for Health, Adaptation, and Recovery in Athletes.http://journals.humankinetics.com/view/journals/ijsnem/28/2/article-p188.xml
- The Effect of Abnormal Vitamin D Levels in Athletes. https://doi.org/10.7812/TPP/17-216
- Sports Health Benefits of Vitamin D. https://doi.org/10.1177/1941738112461621
- The effects of indoor and outdoor sports participation and seasonal changes on vitamin D levels in athletes. https://doi.org/10.1177/2050312119837480
- Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. https://doi.org/10.3390/nu12020579
- Vitamin D and the Immune System. https://doi.org/10.2310/JIM.0b013e31821b8755
- Vitamin D and bone health: potential mechanisms. https://doi.org/10.3390/nu2070693
- Evaluating the relationship of calcium and vitamin D in the prevention of stress fracture injuries in the young athlete: a review of the literature. https://doi.org/10.1016/j.pmrj.2010.05.006
- Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. https://doi.org/10.1210/jc.2008-0350
- Vitamin D and the immune system. https://doi.org/10.2310/JIM.0b013e31821b8755
- Vitamin D and adipogenesis: new molecular insights. https://pubmed.ncbi.nlm.nih.gov/18254883
- Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes. https://pubmed.ncbi.nlm.nih.gov/26899162
- Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042449/